Solely Martin Dúbravka and Joelinton hold their locations from the 2-0 Carabao Cup semi-final first leg win at Arsenal.
Sven Botman, Sandro Tonali, Anthony Gordon, Alexander Isak, Lewis Corridor, Tino Livramento, Jacob Murphy, Joe Willock and Dan Burn all come out of the aspect.
However Fabian Schär returns from suspension and there is nonetheless a substantial amount of expertise and high quality in each the line-up which is able to take to the sphere for the 3pm GMT kick-off and the substitutes.
Dúbravka begins in purpose with Kieran Trippier captaining the staff and Schär becoming a member of the previous England man in defence.
Matt Targett and Lewis Miley make their first begins of the season whereas teenage winger Trevan Sanusi is known as among the many substitutes for the primary time in a aggressive sport.
Tonali, Gordon, Corridor, Livramento, Burn and Guimarães are additionally choices from the bench.
Newcastle United: Martin Dúbravka, Kieran Trippier (c), Fabian Schär, Joelinton, Harvey Barnes, Matt Targett, Will Osula, Miguel Almirón, Lloyd Kelly, Sean Longstaff, Lewis Miley
Substitutes: Odysseas Vlachodimos, Sandro Tonali, Anthony Gordon, Lewis Corridor, Tino Livramento, Dan Burn, Alex Murphy, Bruno Guimarães, Trevan Sanusi