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JCR Pharmaceuticals Announces 52-Week Interim Data from its Global Phase I/II Study of JR-171 in Individuals with Mucopolysaccharidosis Type I (MPS I)

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– JCR to Host Webinar on October 4, 2023, to Present Further Details –

HYOGO, Japan–(BUSINESS WIRE)–JCR Pharmaceuticals Co., Ltd. (TSE 4552; Chairman and President: Shin Ashida; “JCR”) announced today key results from the 52-week interim data of its global phase I/II study with JR-171 (INN: lepunafusp alfa) in individuals with mucopolysaccharidosis type I (MPS I, also known as Hurler, Hurler-Scheie and Scheie syndrome). JR-171 is a blood brain-barrier (“BBB”)-penetrating form of recombinant α-L-iduronidase that was developed using JCR’s proprietary J-Brain Cargo® technology. There are no approved therapies that cross the BBB and address the central nervous system (CNS) symptoms for individuals with MPS I.

JCR Pharmaceuticals Logo

The overall safety data concluded that JR-171 is suitable for the long-term treatment of individuals with MPS I. Although treatment duration and the number of individuals enrolled were not intended to demonstrate an effect on CNS symptoms, preliminary data suggest that JR-171 may provide a beneficial effect on neurological disease burden in symptomatic individuals. Somatic biomarkers remained stable in individuals previously exposed to α-L-iduronidase and were significantly reduced in the one individual who was treatment-naïve. This indicates that JR-171 provides somatic disease control comparable to somatic enzyme replacement therapy (ERT). Concentrations of substrate in the cerebrospinal fluid, which may indicate an effect of substrate reduction in the CNS, were significantly reduced in all patients.

“It is encouraging to observe additional changes in communication, executive functioning, and other aspects important in daily life for those individuals treated with JR-171, in addition to achieving the primary and secondary endpoints,” said Paul Harmatz, MD, investigator at the UCSF Benioff Children’s Hospital Oakland. “Based on these data, JR-171 has the potential to treat both the somatic and neurological symptoms of individuals with MPS I, which is ultimately what is needed.”

JCR Pharmaceuticals plans to host a webinar on October 4, 2023, to present further details of the 52-week results of the clinical study. To register for the webinar, please use the following link https://us06web.zoom.us/webinar/register/WN_vLm-1crCQRqIA5gvk0ArkQ.

There is no impact on the consolidated business results for this fiscal year ending on March 31, 2024, related to the matter.

About JR-171

JR-171 is a recombinant fusion protein of an antibody against the human transferrin receptor and α-L-iduronidase, the enzyme that is missing or malfunctioning in subjects with MPS I. By crossing the blood brain-barrier (“BBB”) through transferrin receptor mediated transcytosis it is expected to be effective against central nervous system (“CNS”) signs and symptoms of the disease thereby addressing a significant unmet need for the treatment of MPS I. JR-171 previously was granted Fast Track designation by the US Food and Drug Administration (FDA).

The phase I/II clinical study is being conducted at several centers in Brazil, Japan and the United States and is composed of two parts: Part one of the open-label study is a 4-week dose-escalation study in adult individuals with MPS I, while part 2 compares two doses of JR-171 in pediatric and adult individuals with MPS I. The main objectives of the phase I/II clinical study are to establish the safety of chronic dosing of JR-171 in individuals with MPS I, the pharmacokinetics of JR-171, to investigate somatic disease control based on biomarkers and somatic endpoints, and to explore early signs of efficacy on central nervous signs and symptoms of MPS I.

At WORLDSympoisumTM 2023 in February 2023, JCR already presented that the reduction of cerebrospinal fluid biomarker was observed in all patients, and biomarkers in serum and urine decreased (in treatment-naïve subjects) or were stable (in enzyme replacement therapy (“ERT”)-experienced subjects) upon treatment with JR-171 for 12 weeks.

There were no drug-related serious adverse events (SAEs) reported during the study. Drug-related adverse events (AEs) and formation of anti-drug antibodies were comparable to profiles typically observed with somatic ERT. There were no gross differences in the safety profile of JR-171 at either dose level tested.

About the J-Brain Cargo® Platform Technology

JCR Pharmaceuticals has developed a proprietary BBB-penetrating technology J-Brain Cargo®, to bring biotherapeutics into the CNS. The first drug developed based on this technology and approved in Japan for the treatment of MPS II (mucopolysaccharidosis type II) is IZGARGO® (INN: pabinafusp alfa). Based on the same platform technology, JR-171 is the second program advancing into global clinical stage. JCR intends to start clinical trials on five additional programs from its LSD pipeline by 2028.

About MPS I (Hurler, Hurler-Scheie, Scheie syndrome)

MPS I is an autosomal recessive lysosomal storage disorders (“LSD”) caused by a deficiency of α-L-iduronidase, an enzyme that breaks down glycosaminoglycans (mucopolysaccharides) in the body. The current worldwide prevalence of MPS I is estimated to be approximately 3,000 (according to JCR internal research). MPS I gives rise to a wide range of somatic and neurological symptoms. A major limitation of current ERT is that it does not address CNS symptoms because of the enzyme’s inability cross the BBB. MPS I is the only LSD in which hematopoietic stem cell transplantation (“HSCT”) is part of the standard of case in the severe form of the disease. Significant unmet medical need persists in all forms of MPS I.

About JCR Pharmaceuticals Co., Ltd.

JCR Pharmaceuticals Co., Ltd. (TSE 4552) is a global specialty pharmaceuticals company that is redefining expectations and expanding possibilities for people with rare and genetic diseases worldwide. We continue to build upon our 48-year legacy in Japan while expanding our global footprint into the US, Europe, and Latin America. We improve patients’ lives by applying our scientific expertise and unique technologies to research, develop, and deliver next-generation therapies. Our approved products in Japan include therapies for the treatment of growth disorder, Fabry disease, acute graft-versus host disease, and renal anemia. Our investigational products in development worldwide are aimed at treating rare diseases including MPS I (Hurler, Hurler-Scheie and Scheie syndrome), MPS II (Hunter syndrome), MPS III A and B (Sanfilippo syndrome type A and B), and more. JCR strives to expand the possibilities for patients while accelerating medical advancement at a global level. Our core values – reliability, confidence, and persistence – benefit all our stakeholders, including employees, partners, and patients. Together we soar. For more information, please visit https://www.jcrpharm.co.jp/en/site/en/.

Cautionary Statement Regarding Forward-Looking Statements

This document contains forward-looking statements that are subject to known and unknown risks and uncertainties, many of which are outside our control. Forward-looking statements often contain words such as “believe,” “estimate,” “anticipate,” “intend,” “plan,” “will,” “would,” “target” and similar references to future periods. All forward-looking statements regarding our plans, outlook, strategy and future business, financial performance and financial condition are based on judgments derived from the information available to us at this time. Factors or events that could cause our actual results to be materially different from those expressed in our forward-looking statements include, but are not limited to, a deterioration of economic conditions, a change in the legal or governmental system, a delay in launching a new product, impact on competitors’ pricing and product strategies, a decline in marketing capabilities relating to our products, manufacturing difficulties or delays, an infringement of our intellectual property rights, an adverse court decision in a significant lawsuit and regulatory actions.

This document involves information on pharmaceutical products (including those under development). However, it is not intended for advertising or providing medical advice. Furthermore, it is intended to provide information on our company and businesses and not to solicit investment in securities we issue.

Except as required by law, we assume no obligation to update these forward-looking statements publicly or to update the factors that could cause actual results to differ materially, even if new information becomes available in the future.

Contacts

Investors & Media:

JCR Pharmaceuticals Co., Ltd.

Corporate Communications

[email protected]

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Best AI Essay Writing Tools That Will Save You Time and Money in 2023 (Review)

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Best AI Essay Writing Tools That Will Save You Time and Money in 2023 (Review)

We all have been there when our minds are flowing with ideas but we can’t find words to write them down. We also have been at the point where we just don’t have ideas to begin with. 

But we can’t just discuss these issues and not give you a solution. We all know about the advancements in AI, but did you know that there are tools to help students with essay writing?

In this article, we will introduce you to amazing AI essay writing tools that will help you create compelling essays that captivate, inform, and impress. 

We will break down their features and pricing to help you make an informed choice that meets your needs and budget.

So let’s get started!

PerfectEssayWriter.ai – The Ultimate Essay Solution

PerfectEssayWriter.ai - The Ultimate Essay Solution

PerfectEssayWriter.ai – The Ultimate Essay Solution

PerfectEssayWriter.ai is a true wonder when it comes to using artificial intelligence for essay writing in multiple languages.

This AI essay writer has a variety of features that work together to take your writing experience to the next level.

Best Features

  • 26 Templates for Diverse Essay Styles: PerfectEssayWriter.ai offers writing templates for different styles and formats, making it easier to structure content.
  • AI Essay Writer for Seamless Composition: PerfectEssayWriter.ai’s AI essay writer uses advanced algorithms to generate well-structured, coherent essays. It also suggests relevant vocabulary and phrases.
  • Paragraph Generator for Structured Flow: Its paragraph generator can help you ensure that your essay has a logical flow and seamlessly guides the reader through your ideas.
  • Paraphrasing Tool to Enhance Originality: The paraphrasing tool helps you add credibility to your work by rewriting sentences and thoughts while keeping the core message intact.

Pricing

PerfectEssayWriter.ai offers flexibility in its pricing plans:

Basic Plan: $29.99 $5.99/month (Limited Time Offer)

Pro Plan: $74.99 16.99/month (Limited Time Offer)

Advanced Yearly Plan: $179.88 99.99/year (4 Month Free – Limited Time Offer)

MyEssayWriter.ai – Elevate Your Academic Writing

MyEssayWriter.ai - Elevate Your Academic Writing

MyEssayWriter.ai – Elevate Your Academic Writing

Quality is a key concern for many students, and MyEssayWriter.ai is here to assist them with their essay writing hurdles. 

This essay writer is designed to simplify the essay-writing process while ensuring your content meets the highest standards.

Best Features

  • AI Essay Writer for Efficient Essay Writing: By utilizing artificial intelligence, it assists you in generating essays that are not only coherent but also well-crafted.
  • AI Essay Outliner for Clear Organization: MyEssayWriter.ai’s AI essay outliner helps you organize your thoughts, ensuring that your essay follows a logical progression.
  • Plagiarism Checker to Ensure Authenticity: MyEssayWriter.ai includes a built-in plagiarism checker that scans your content against a vast database.

Pricing

MyEssayWriter.ai keeps your budget in mind:

Basic Plan: $29.99 $9.99/month (Limited Time Offer)

Pro Plan: $74.99 14.99/month (Limited Time Offer)

Advanced Plan: $179.88 $99.99/year (4 Month Free – Limited Time Offer)

EssayService.ai – Your Last-Minute Essay Solution

EssayService.ai - Your Last-Minute Essay Solution

EssayService.ai – Your Last-Minute Essay Solution

When you’re seeking an AI essay writing tool that adapts to your academic level and caters to your essay’s specific word count, EssayService.ai steps up to the plate. 

This essay generator is designed to bridge the gap between your unique requirements and flawless essay creation.

Best Features

  • AI Essay Writer for Customizable Essays: Its AI essay writer tailors content to match your specific needs, ensuring your essay meets the expectations of your instructors.
  • Accommodates Different Academic Levels: Whether you’re in high school, college, or pursuing advanced studies, EssayService.ai adapts its writing style to suit your academic level. 
  • Ability to Specify Word Count: EssayService.ai gives you the authority to define the length of your essay, ensuring you stay within the prescribed limits without sacrificing quality.

Pricing

EssayService.ai is the go-to option for students on a budget because it is entirely FREE!

CollegeEssay.org AI Essay Writer – Generate Essays With Ease

CollegeEssay.org AI Essay Writer - Generate Essays With Ease

CollegeEssay.org AI Essay Writer – Generate Essays With Ease

For students seeking a comprehensive AI-powered writing companion, CollegeEssay.org AI stands as a robust solution. 

With a number of tools designed to refine various aspects of your essay, this essay typer aims to transform your writing into a polished masterpiece.

Best Features

  • AI Essay Writer for Seamless Composition: The AI essay writer simplifies the writing process by offering suggestions and guidance. It serves as a valuable co-author, helping you craft compelling essays.
  • Plagiarism Checker to Ensure Originality: CollegeEssay.org AI’s built-in plagiarism checker scans your content for similarities across a vast database. It makes sure that your work is genuinely your own.
  • Grammar Checker for Polished Writing: CollegeEssay.org AI’s grammar checker identifies grammatical mistakes and suggests corrections, allowing you to present error-free content.
  • Content Paraphraser for Enhanced Uniqueness: Paraphrasing content is a skill that CollegeEssay.org AI excels in. It assists in rephrasing sentences and passages, enhancing the uniqueness of your essay.
  • Citation Finder for Accurate References: Proper citations lend credibility to your work. CollegeEssay.org AI’s citation finder ensures your references are accurate and follow the prescribed citation style.

Pricing

CollegeEssay.org AI offers value and a trial period:

Basic Plan: FREE

Premium Plan: $29.99 7.99/month (Limited Time Offer)

Advanced Yearly Plan: $359.88 39.92/year (Limited Time Offer)

EssayBot by MyPerfectWords.com – Quick Essay Generation

EssayBot by MyPerfectWords.com - Quick Essay Generation

EssayBot by MyPerfectWords.com – Quick Essay Generation

When versatility is a priority and you’re in search of an essay bot that can generate essays on a wide range of topics, EssayBot emerges as a reliable option. 

Best Feature

  • Generates Essays on a Wide Range of Topics: EssayBot excels at generating essays on a wide range of topics. Whether you’re writing about history, science, literature, or anything else, EssayBot can help.

Pricing

Basic Plan: FREE

Premium Plan: $29.99 6.99/month (Limited Time Offer)

Advanced Yearly Plan: $359.88 39.92/year (Limited Time Offer)

FreeEssayWriter.ai – Affordability and Quality Guaranteed

FreeEssayWriter.ai - Affordability and Quality Guaranteed

FreeEssayWriter.ai – Affordability and Quality Guaranteed

FreeEssayWriter.ai is the newest and most reliable option for students. Not only that, this free AI essay writer offers multiple features for students to help them improve their essays.

Best Features

  • Instant Essay Outline Generator: FreeEssayWriter.ai boasts lightning-fast essay generation. With its advanced AI algorithms, you can create essays in record time, freeing you from the clutches of looming deadlines.
  • AI Essay Editor for Precision: Not just a writer, FreeEssayWriter.ai serves as your personal editor. It fine-tunes your content for grammar, style, and coherence, ensuring your essays are nothing short of perfection.
  • Citation Generator for Academic Excellence: Proper citations are a must in academic writing. FreeEssayWriter.ai simplifies this process by generating accurate citations in various citation styles, making your work academically impeccable.

Pricing

FreeEssayWriter.ai lives up to its name as it is entirely FREE!

So there you have it!

AI essay writing tools have emerged as valuable assets for students. From crafting well-structured essays to ensuring authenticity, each tool brings a unique set of features to the table. 

As you navigate your academic journey, consider these AI-powered platforms to enhance your essay-writing prowess. 

With AI, you can write better essays faster and easier than ever before. 

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Inclusive Hiring Now and in the Future

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Easter Seals Greater Houston

HOUSTON, Sept. 29, 2023 /PRNewswire/ — Nearly a third of students with disabilities do not graduate from high school. A truly staggering number when you consider that over 3 million children have a disability according to the recent census. But with the right resources, a diagnosis is no longer sealing children’s futures, just ask Allan Brizuela, a client turned invaluable team member at Easter Seals Greater Houston (ESGH).

In 2015, Allan began participating in Easter Seals Greater Houston’s High School High Tech (HSHT) and Ready to Achieve Mentoring Program (RAMP). These programs offer learning experiences to students with disabilities that encourage career exploration and broaden educational horizons. Typically, only 70.6% of students with disabilities graduate from high school, but when enrolled in our HSHT that success rate jumps to 99%. HSHT and RAMP students develop social skills, self-confidence, and work readiness skills through resume training, mentorship, mock interviews, and internships. Over the years, Allan also traveled to Washington D.C. to participate in RAMP Conferences and participated in the Youth Employment Policy Convening, helping to create a youth employment policy framework.

After graduating, Allan began volunteering as a Junior Mentor at his alma mater where he helped guide students through the RAMP program. He was also very interested in gaining work experience and was hired for a summer internship in the nonprofit’s Human Resources Department. Allan put his RAMP and HSHT skills to work and proved to be an excellent intern. Everyone, especially his former RAMP Coordinator, was so excited and proud when he accepted a permanent position and officially joined the ESGH team as part of the Respite Program.

This year, with training and support from Allan, his fellow mentors, and HSHT/RAMP staff, 14 students with all types of disabilities were interviewed and hired as interns. These young adults gained crucial work experience at Catholic Charities, Clear Creek ISD Technology Learning Center, CVS, Distinct Abilities Academy, Happy Faces Pet Ranch, Meals on Wheels Conroe, and Red Oak Café. The businesses that hosted the interns gave them an opportunity to test and grow their skills. In return, they got 14 incredibly hard workers who just needed a chance to prove themselves. At the Internship Celebration Luncheon, one manager said he learned about himself as a supervisor and his preconceived ideas about people with disabilities, and said the experience “gave him tools for his toolbox.” Another manager talked about how her intern “came to work early every day with a smile on her face; no job was too big or too small – what a great example she was to everyone.”

These interns’ lives are forever changed. ESGH’s crucial programs for teens and young adults are keeping them in school, showing them a path to independence, and building their confidence and skillset so they can reach the height of their potential. HSHT and RAMP also create an environment for business leaders to see the potential of inclusive hiring. October is National Disability Employment Awareness Month. Take a moment to consider how your workplace could mutually benefit from diversifying your hiring practices. Please contact our HSHT and RAMP Director, Kristie Carlisle, at [email protected] or 713.838.9050 ext. 363 to learn more about hiring and internship opportunities. Together, we can empower people with disabilities to be full and equal participants in the workforce.

About Easter Seals Greater Houston
As a lead affiliate in our national network of 69 affiliates in 48 states, Easter Seals Greater Houston impacts people where they need us most — school, work, home, and in the community — from the critical first five years of life onward. Each year we directly serve over 14,500 people, providing early childhood and therapy services, mental health, employment programs, adult day programs, Military and Veterans’ services, and more. 

For children and adults with disabilities, for veterans and service members, for seniors, and for families and caregivers through Harris and 16 surrounding counties, ESGH is leading the way to full equity and inclusion through life changing disability and community services. With the help of our community, we are reducing poverty and addressing financial stability; improving healthcare and employment, and empowering people of all ages and abilities to be full and equal participants in our community. ESGH operates: Early Childhood Intervention; Respite Services; Toy/Tech & Play Groups, BridgingApps© (bridgingapps.org); High School/High Tech; Financial Education and Down Payment Assistance; Children’s Therapy Services; The Caroline School, Camps, Case Management, Employment/Transition Services; Adult Recreation, and Military/Veterans Services. For more information about ESGH, visit www.eastersealshouston.org or follow us on Facebook, Instagram, and X.


(PRNewsfoto/Easter Seals Greater Houston)

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Agricultural Tires Market Size, Demand, Share, Growth & Forecast 2023-2028

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The global agricultural tires market size reached US$ 7.7 Billion in 2022.

UNITED STATES, September 29, 2023 /EINPresswire.com/ — The latest report by IMARC Group, titled “Agricultural Tires Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2023-2028”, offers a comprehensive analysis of the industry, which comprises insights on the global agricultural tires market share. The global agricultural tires market size reached US$ 7.7 Billion in 2022. Looking forward, IMARC Group expects the market to reach US$ 10.3 Billion by 2028, exhibiting a growth rate (CAGR) of 5.1% during 2023-2028.

Agricultural or ag tires are specialized tire types designed exclusively for use on agricultural vehicles and equipment. These tires are meticulously engineered to endure the demanding conditions found in farm environments, where heavy machinery operates on rugged and often uneven terrain. They come in various varieties tailored to suit distinct farming applications, such as tractors, combines, harvesters, and other types of farm equipment. These tires are equipped with deep treads and robust sidewalls to provide the necessary traction, stability, and durability required in fields, muddy soils, and off-road situations. The careful selection of agricultural tires is of utmost importance to maximize productivity while minimizing soil compaction, which can have adverse effects on crop yields and the overall health of farmland. Currently, agricultural tires are extensively employed in modern farming practices, significantly enhancing the efficiency and productivity of agricultural machinery in a wide range of crop cultivation and harvesting tasks worldwide.

Request Your Sample Report Now: https://www.imarcgroup.com/agricultural-tires-market/requestsample

Agricultural Tires Market Trends and Drivers:

The global agricultural tires market is primarily being propelled by the rapid expansion of the agriculture industry, driven by the increasing demand for food. Furthermore, the growing necessity for robust and high-performing agricultural tires, driven by the widespread adoption of modern mechanized equipment, is having a positive impact on market growth. In addition to this, numerous tire technology advancements, such as the introduction of radial tires that enhance tire longevity and performance, have accelerated market growth. Moreover, there is a multitude of product innovations in the form of eco-friendly and fuel-efficient tires, prompted by escalating concerns about sustainability and the industry’s growing emphasis on reducing environmental impact, which are driving market growth. Additionally, the increasing adoption of precision agriculture practices has heightened the demand for specialized tires tailored for specific farming applications, further contributing to the expansion of the market.

Competitive Landscape:

The competitive landscape of the market has been studied in the report with the detailed profiles of the key players operating in the market.

Some of these key players include:

Apollo Tyres Limited
Balkrishna Industries Limited (BKT)
Bridgestone Corporation
CEAT Ltd. (RPG Group)
Continental AG
JK Tyre & Industries Ltd.
MRF Limited
Specialty Tires of America Inc.
Sumitomo Rubber Industries Ltd.
TBC Corporation (Michelin)
The Carlstar Group LLC
Titan International Inc.
Trelleborg AB
Yokohama Off-Highway Tires America Inc. (Yokohama Rubber Company).

Ask Analyst for Sample Report: https://www.imarcgroup.com/request?type=report&id=3644&flag=C

The report has segmented the market on the basis of Product Type, Distribution Channel, Packaging Type and Region.

Breakup by Product Type:

Bias Tires
Radial Tires

Breakup by Application:

Tractors
Harvesters
Forestry
Irrigation
Trailers
Others

Breakup by Distribution Channel:

OEM
Aftermarket

Breakup by Region:

North America (United States, Canada)
Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, Others)
Europe (Germany, France, United Kingdom, Italy, Spain, Russia, Others)
Latin America (Brazil, Mexico, Others)
Middle East and Africa

If you need specific information that is not currently within the scope of the report, we will provide it to you as a part of the customization.

About Us

IMARC Group is a leading market research company that offers management strategy and market research worldwide. We partner with clients in all sectors and regions to identify their highest-value opportunities, address their most critical challenges, and transform their businesses.

IMARC’s information products include major market, scientific, economic and technological developments for business leaders in pharmaceutical, industrial, and high technology organizations. Market forecasts and industry analysis for biotechnology, advanced materials, pharmaceuticals, food and beverage, travel and tourism, nanotechnology and novel processing methods are at the top of the company’s expertise.

Contact US

IMARC Group

Email: [email protected]

USA: +1-631-791-1145 | Asia: +91-120-433-0800

Address: 134 N 4th St. Brooklyn, NY 11249, USA

Follow us on Twitter: @imarcglobal

Elena Anderson
IMARC Services Private Limited
+1 631-791-1145
email us here

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